在基底腺节中风后,thalamic亚区域的功能连接性发生变化
Qiansheng Cheng1,2, Shoufeng Liu2,3, Junling Wang2,3
1Department of Radiology, Tianjin Huanhu Hospital, Tianjin, China.
Frontiers in neurology
|June 23, 2025
概括
基底节中风改变了皮层网络中的功能连接 (FC),影响了运动和认知功能. 这些特定的FC变化可以作为恢复和个性化康复策略的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是指放射学
- 神经学 神经学
背景情况:
- 基底 (BG) 中风经常导致运动和认知障碍,但根本的神经生物学机制尚未完全理解.
- 为了了解这些缺陷,研究BG中风后的乳头亚区域功能连接 (FC) 的变化至关重要.
研究的目的:
- 通过静止状态功能磁共振成像 (rs-fMRI) 探索基底 (BG) 卒中患者的thalamic亚区域之间的功能连接 (FC) 的变化.
- 为了将观察到的FC变化与运动和认知评估得分相关联.
主要方法:
- 一项涉及40名BG中风患者和35名健康对照者的横截面研究.
- 在14个thalamic亚区域进行了基于种子的FC分析.
- 评估了FC变化与Fugl-Meyer评估 (FMA) 和迷你心理状态考试 (MMSE) 分数之间的相关性.
主要成果:
- 患有BG中风的患者表现出改变的FC,包括左侧SC_thalamus和左侧precuneus之间的超连接,以及右侧SC_thalamus和左侧角圈.
- 观察到左侧PFC_thalamus和右侧上边缘环,左侧TC_thalamus和右侧后中心环,以及右侧M1_thalamus和右侧中间上额头环之间存在低连接性.
- 右M1_thalamus和中间上额头回环之间的FC强度与FMA分数呈正相关,而PFC_thalamus-supramarginal连接性预测了MMSE表现.
结论:
- 基底节中风会在亚区域层面中破坏甲状腺皮质电路,与运动和认知缺陷相关的明显的FC模式.
- 这些网络层面对FC变化的洞察力可能有助于指导针对性的神经调节疗法.
- 鉴定的FC变化可以作为监测康复和个性化干预措施的生物标志物,以提高中风后康复结果.
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