人类微生物组与结石有什么联系?
Xin Pei1, Miao Liu2, Shanshan Yu3
1Department of Urology, China-Japan Union Hospital, Jilin University, Changchun, China.
Frontiers in cellular and infection microbiology
|June 23, 2025
概括
肠道和尿道微生物群显著影响结石的形成. 变化的微生物多样性和功能,特别是减少的氧酸盐降解细菌,与增加石头风险和疾病进展有关.
科学领域:
- 微生物学 微生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 胃肠病学 胃肠病学
背景情况:
- 全球结石的发病率正在上升,常规治疗对于复杂的病例通常是无效的.
- 主体微生物组在新陈代谢调节,免疫平衡和炎症方面发挥着至关重要的作用,影响结石的发育.
- 尿路和肠道微生物组在健康人群和石患者之间存在差异,患者的多样性和关键细菌功能减少.
研究的目的:
- 探索微生物组与结石病原体之间的复杂关系.
- 为了确定与结石形成和疾病复发相关的微生物变化.
- 评估基于微生物组的诊断和治疗结石的潜力.
主要方法:
- 在结石患者和健康对照患者的尿道和肠道微生物组的比较分析.
- 研究微生物代谢途径及其对尿液化学和结石形成的影响.
- 关于微生物组相关风险因素和结石潜在干预措施的当前文献的综述.
主要成果:
- 石患者的微生物多样性减少,有益细菌的丰富性降低,例如氧沙酸盐降解物种.
- 失生症通过改变的代谢物,尿液pH值的变化和炎症反应促进石头的形成.
- 特定的细菌,如生产尿素酶的Proteus mirabilis,与特定的石头类型 (例如氨酸) 有关.
结论:
- 微生物组是结石发育和复发的关键因素.
- 基于微生物组的诊断标志物和干预措施,如益生菌和便微生物群移植,显示出有希望的结果.
- 进一步的研究,整合多omics数据和个性化疗法是必要的,以充分理解和管理微生物组相关的结石.
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