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全免疫炎症值对A型大动脉解剖患者的短期结果和长期预后的影响
Hao Cai1, F M Shourav1, Yue Shao1
1Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Journal of inflammation research
|June 23, 2025
概括
全免疫炎症值 (PIV) 预测了急性A型大动脉剖析 (TAAD) 的结果. 高PIV与更糟糕的短期结果有关,而低PIV则表明TAAD患者的长期生存率更好.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 外科手术的结果
背景情况:
- 炎症反应对大动脉剖析的发展和进展至关重要.
- 全免疫炎症值 (PIV) 是一种基于血液的指数,在各种疾病中具有预后价值.
- 在急性A型大动脉剖析 (TAAD) 中PIV的预测作用仍未得到充分研究.
研究的目的:
- 评估术前泛免疫炎症值 (PIV) 与急性TAAD患者的短期和长期结果之间的关联.
- 确定PIV是否可以作为TAAD患者早期风险分层工具.
主要方法:
- 对171名接受手术修复的急性TAAD患者的回顾性分析 (2017年9月 - 2020年12月).
- 接收器操作特征 (ROC) 曲线分析以确定最佳的PIV切断点.
- 低PIV和高PIV组之间的短期结果 (ICU停留,并发症) 和长期存活率的比较,使用后勤和Cox回归.
主要成果:
- 与低PIV组 (n=75) 相比,高PIV前手术患者 (n=96) 的手术时间更长,血液损失增加,输血需要更高,ICU停留时间更长,整体/重大并发症更多.
- 高PIV是长时间ICU停留 (OR=0.686),整体并发症 (OR=0.037) 和重大并发症 (OR=0.085) 的独立预测因素.
- 较低的手术前PIV水平与改善的长期存活率 (HR=0.757) 有意义地相关.
结论:
- 手术前泛免疫炎症值 (PIV) 是一种独立的预测器,用于预测急性TAAD的短期不良结果,包括长时间的ICU停留和并发症.
- 在TAAD患者中,较低的PIV水平与更好的长期存活相关.
- PIV作为一个有价值的综合生物标志物,用于评估系统性炎症,并帮助在急性TAAD管理中的风险分层.
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