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中性细胞外细胞陷 (NETs) 在无菌炎症疾病中

Yin-Min Ji^1,2,3, Tao Li^1,3,4,5, Yu-Hui Qin^1,3

¹Senior Department of Oncology, the First Medical Center of PLA General Hospital, Beijing, 100853, People's Republic of China.

Journal of inflammation research

|June 23, 2025

概括

中性细胞外细胞陷 (NETs) 是对抗病原体的DNA网络,但也可能导致组织损伤. 本综述探讨了NET如何在各种疾病中驱动无菌炎症.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
病理学病理学病理学

背景情况:

中性粒细胞外细胞陷 (NETs) 是由中性粒细胞释放的.
网由DNA,基因组和蛋白质组成,捕获和杀死病原体.
NETs还可以损害宿主组织并导致炎症.

研究的目的:

审查NETs在调解无菌炎症中的机制.
讨论NET在宿主防御和疾病发病过程中的双重作用.

主要方法:

关于NET研究的文献综述.
分析NET的组成和功能.
检查NETs在各种疾病中的参与.

主要成果:

网对于消除病原体至关重要.
NETs可能会导致组织损伤并加剧炎症.
NETs与自身免疫性疾病,癌症和感染有关.

结论:

网络在免疫和疾病中起着复杂的作用.
了解NET的机制是治疗炎症疾病的关键.

关键词:

国际投资机构 (ICI) 是国际投资机构 (ICI) 的一个组成部分.自身免疫性疾病自身免疫性疾病细胞外的陷细胞外的陷免疫检查点抑制剂免疫检查点抑制剂中性粒细胞中性粒细胞.无菌炎症是一种无菌的炎症.

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