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甲作为急性胰腺炎的未被认可的原因:一个案例报告和文献综述
Daniel Hahn1, Jasmine Fung1, Angela Tran1
1Internal Medicine, Touro College of Osteopathic Medicine, New York, USA.
Cureus
|June 23, 2025
概括
药物诱导的急性胰腺炎 (DIAP) 经常被忽视. 这一案例突出显示了甲酸是潜在的原因,强调了对无法解释的胰腺炎的药物审查.
科学领域:
- 胃肠病学和内科医学
- 临床药理学 临床药理学
背景情况:
- 急性胰腺炎是一种普遍的胰腺炎症状况.
- 常见的病因包括胆结石,酒精和异常因素.
- 药物诱导的急性胰腺炎 (DIAP) 是一个未被认可的原因,需要对药物进行警评估.
研究的目的:
- 报告急性胰腺炎的病例,这种病例可能是由甲酸诱导的.
- 强调在患有无法解释的胰腺炎的患者中考虑DIAP的重要性.
主要方法:
- 一份病例报告显示,一名72岁的男性患者呈现急性胰腺炎症状.
- 排除常见的胰腺炎原因 (胆结石,酒精,高甘油三血).
- 根据药物 anamnesis 和临床表现,确定甲酸作为潜在的致病剂.
主要成果:
- 患者呈现出表胃疼痛,脂酶升高,以及与急性胰腺炎一致的成像.
- 在排除其他原因后,化物化物被确定为可能的触发因素.
- 停用甲酸导致临床改善和实验室值的正常化.
结论:
- 甲酸可以导致急性胰腺炎.
- 临床警和彻底的药物检查对于诊断DIAP至关重要.
- 考虑DIAP至关重要,特别是在患有并发症和不明原因胰腺炎的患者中.
相关概念视频
Acute Pancreatitis I: Introduction
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Clinical Manifestations and Management
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Chronic Pancreatitis I: Introduction
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Acute Pancreatitis I: Introduction
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis II: Pathophysiology
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Chronic Pancreatitis I: Introduction
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

