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Updated: Sep 18, 2025

Affinity Precipitation of Active Rho-GEFs Using a GST-tagged Mutant Rho Protein GST-RhoAG17A from Epithelial Cell Lysates
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Published on: March 31, 2012

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通过PH域中的酸化来调节Rho关氨酸核酸交换因子3的调节

Jesus F Moreno1, Jae-Sung You1, Carlos C Rodriguez2,3,4

  • 1Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

iScience
|June 23, 2025
PubMed
概括

通过蛋白激酶C (PKC) 在其PH域中的ARHGEF3的酸化抑制了RhoA信号传递和actin应力纤维的形成. 这揭示了罗氨酸核酸交换因子 (RhoGEFs) 的新型调节机制.

关键词:
生物化学 生物化学在 silico 生物学.分子生物学分子生物学

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