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Updated: Sep 18, 2025

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

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通过 lysosomal trafficking 进行针对性mRNA降解的工程反意义寡核酸

Disha Kashyap1,2, Thomas A Milne2, Michael J Booth1,3

  • 1Department of Chemistry, University of Oxford Mansfield Road Oxford OX1 3TA UK m.j.booth@ucl.ac.uk.

Chemical science
|June 23, 2025
PubMed
概括

反感性寡核酸 (ASOs) 现在可以通过溶酶体降解来向细胞质mRNA. 这种新的溶酶体贩运反感性寡核酸 (LyTON) 技术增强了基因沉默,用于更广泛的治疗应用.

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