患有Helicobacter pylori感染的儿童的胃癌
Xia Gong1, Cen Chen1, Jun-Fei Shen2
1Department of Pediatrics, Dazu Hospital of Chongqing Medical University, Chongqing 402360, China.
World journal of gastrointestinal oncology
|June 23, 2025
概括
童年 杆菌 (H.pylori) (H. 甲状腺炎感染与癌前胃状况有关. 胃癌家族病史可能会增加风险,强调早期检测和干预的必要性.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 甲状腺杆菌 (H. pylori) 是一种 童年时期的甲状腺炎感染是胃癌的潜在危险因素.
- 家庭癌症史是胃癌的已知危险因素.
- 童年和H.之间的相互作用 在胃癌的发展需要进一步的调查.
研究的目的:
- 为了定义童年和H之间的关联. 杆菌感染和胃癌的危险因素.
- 具体评估家族癌症史在这种关联中的作用.
主要方法:
- 对600名儿童上部胃肠道内镜数据的回顾性分析.
- 儿童被分类为H. 根据活检和快速尿素酶测试的基础上,阳性和阴性小组.
- 两组之间的胃癌,慢性表面性胃炎,腺缩和肠道转化发生率的比较.
主要成果:
- 在 H.I. 中, 在儿科研究人口中,有55% (330/600) 患有甲状腺炎感染.
- 在 H.I. 中, 胆固醇阳性儿童的慢性表面性胃炎 (78.8%与5.9%相比),胃缩 (39.4%与7%相比) 和肠道代谢 (0.9%与0%) 的发生率明显高于H. 皮洛里阴性儿童.
- 在H.之间观察到具有统计意义的关联. 脊柱瘤阳性和胃癌家族病史 (1.2%与0%相比).
结论:
- 童年 H. 小时候 甲状腺炎感染与癌前胃病的风险增加有关.
- 胃癌家族病史可能是感染H的儿童的额外危险因素. 皮洛里. 皮洛里.
- 早期发现,干预和管理H.I. 建议在童年时使用杆菌,特别是对于有胃癌家族病史的儿童.
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