在性结肠炎中,患者对疾病活动的感知和内镜评估之间的矛盾
Boilève Juliette1, Trang-Poisson Caroline1, Flamant Mathurin2
1Institut des Maladies de l'Appareil Digestif, Hépato-Gastro-Entérologie et Assistance Nutritionnelle, Inserm CIC 1413, Nantes Université, CHU Nantes, Nantes, France.
Therapeutic advances in gastroenterology
|June 23, 2025
概括
患者对性结肠炎 (UC) 活动的感知往往与内镜检查结果不匹配. 像直肠出血,腹痛和肠急症这样的症状与疾病严重程度比便频率更好地相关.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 临床试验分析
背景情况:
- 在性结肠炎 (UC) 中,患者报告的症状和内镜评估之间存在重大差异.
- 现有的研究主要集中在患者报告的结果上,而不是他们对疾病活动的整体感知.
研究的目的:
- 评估患者全球评估 (PtGA) 和UC内镜检查结果之间的一致性.
- 确定影响本协议的因素.
- 为了比较患者和医生对UC疾病活动的看法.
主要方法:
- 一项前性观察性研究包括了104名接受柔性西格莫显镜检查的UC患者.
- 使用梅奥内镜子子评分 (MES) 和PtGA评估一致性.
- 炎症性肠病 (IBD) - 盘点项目分析了与一致性相关的因素.
主要成果:
- 只有32.7%的患者在PtGA和MES之间完全保持一致.
- 较高的客观疾病活性与患者医生一致性增加相关.
- 结直肠出血,腹痛和肠急性明显与更好的一致性有关,与便频率不同.
结论:
- 患者的感知和内镜评估之间的差异在UC中很常见.
- 腹痛和肠急性,以及直肠出血,可能是比便频率更可靠的临床UC活动指标.
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