BDNF Val66Met多态度适度了老年人身体活动和神经认知结果之间的关联
Claire J Cadwallader1, Anna M VandeBunte1, D Luke Fischer1
1Department of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California San Francisco USA.
Alzheimer's & dementia (New York, N. Y.)
|June 23, 2025
概括
在具有Val/Val脑源性神经营养因子 (BDNF) 基因型的个体中,体力活动对大脑健康的益处更大. 这种基因型可能会增强对阿尔茨海默病标志物的保护作用,改善执行功能,对神经炎症有潜在的性别特异性影响.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 老年学是一门学科.
背景情况:
- 身体活动 (PA) 与大脑衰老的好处有关,可能由来自大脑的神经营养因子 (BDNF) 介导.
- 该BDNF Val66Met多态 (rs6265) 影响活动依赖的BDNF释放,并与阿尔茨海默病 (AD) 风险和认知衰退有关.
- 在BDNF基因型中的个体差异可能会影响PA如何影响老年人大脑健康.
研究的目的:
- 调查BDNF基因型是否调节PA和AD生物标志物,神经炎症和非痴呆老年人的认知功能之间的关联.
- 探索PA,BDNF基因型和性对神经生物学标志物和认知结果之间的潜在相互作用.
主要方法:
- 180名老年人接受了为期30天的动图,以评估PA (平均每日步骤).
- 测量了酸化 (p-tau181),神经丝光链 (NfL) 和状纤维酸性蛋白质 (GFAP) 的血水平.
- 进行了BDNF Val66Met基因定型;123名参与者完成了执行功能和记忆力的神经心理测试.
主要成果:
- BDNF基因型调节了PA-p-tau181关系;更高的PA仅在Val/Val参与者中与较低的p-tau181有关.
- 在Val/Val个体中,p-tau181调解了PA和执行功能之间的关联.
- PA,BDNF基因型和性别的三方相互作用影响了GFAP水平,高的PA仅在Val/Val男性中与较低的GFAP相关.
结论:
- 瓦尔/瓦尔BDNF基因型可能会增强PA的神经保护作用,从而减少AD病理和改善执行功能.
- 在Val/Val男性中,PA可能对神经炎症具有性别特异性的益处.
- 这些发现突出了PA对大脑健康影响的遗传和基于性别的个体变异,为个性化神经营养策略提供了信息.
关键词:
阿尔茨海默氏症的疾病是阿尔茨海默氏症.BDNF Val66Met 单核酸多态化的一种.在GFAPAP中,GFAP是最重要的.印度6265卢比认知 认知 认知健康的衰老健康的衰老身体活动 身体活动血生物标志物 血生物标志物在p-tau 181 181 中.性别差异的性别差异.更多相关视频
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