下相角作为慢性病患者预后不良的标志物:一个队列研究
Yi-Qin Chen1, Hui-Fen Chen1, Yan Han1
1The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
Frontiers in nutrition
|June 23, 2025
概括
慢性病 (CKD) 患者的下相角 (PhA) 是不良预后的独立风险因素. 生物阻抗分析可以帮助评估营养状况,并预测非透析CKD患者的结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物阻抗分析分析
- 营养科学 营养科学
背景情况:
- 来自生物阻抗分析的相角 (PhA) 与透析患者的死亡率和营养不良有关.
- 它与非透析慢性病 (CKD) 患者的预后的关联尚不清楚.
研究的目的:
- 研究非透析CKD患者的PhA和脏预后之间的关系.
- 为了确定PhA是否可以作为不良结局的预测标记.
主要方法:
- 使用生物阻抗测量分析了2,202名非透析CKD患者的队列.
- 使用了考克斯的比例危险分析和基于组的轨迹建模.
- 综合结局包括EGFR下降,SCr升高,透析启动,移植或全因死亡率.
主要成果:
- 较高的PhA四分位数与较差脏预后风险显著降低有关 (Q3:aHR 0.71;Q4:aHR 0.62).
- 一个相角高于5.0°显示出一种保护作用 (aHR 0.77).
- 基于组的轨迹建模确定了4个不同的患者轨迹,较低风险的轨迹显示出明显更好的预后 (aHRs从0.47到0.69).
结论:
- 阶段角是CKD患者营养状况的有价值指标.
- 低相角是非透析CKD患者脏预后不佳的独立风险因素.
- PhA可以帮助风险分层和慢性病患者的管理.
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