全球HPV疫苗接种计划和覆盖率:系统审查
Jingjing Han1,2,3, Li Zhang1, Yuqing Chen3
1School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
EClinicalMedicine
|June 23, 2025
概括
全球人类乳头瘤病毒 (HPV) 疫苗接种覆盖率低于90%的目标,只有47.6%的人在2023年获得全剂量. 需要加强战略,以提高全球HPV免疫率.
科学领域:
- 公共卫生 公共卫生
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 许多国家已经将人类乳头瘤病毒 (HPV) 疫苗纳入其国家免疫接种计划.
- 关于HPV疫苗接种范围的全面全球数据有限.
- 这项研究解决了对全球HPV免疫计划和覆盖范围进行深入分析的需求.
研究的目的:
- 提供当前全球HPV免疫计划的全面概述.
- 评估全球HPV疫苗接种覆盖率.
- 分析HPV疫苗接种和宫癌发病率的趋势.
主要方法:
- 系统搜索PubMed,Embase,世卫组织数据库和HPV疫苗接种政策和194个世卫组织成员国的覆盖率数据的网站.
- 2010-2023年基于人口的HPV疫苗接种覆盖率的分析.
- 评估15个早期采用国家的宫癌发病率趋势和按性别和年龄分类的子组分析.
主要成果:
- 截至2025年2月,148个国家拥有国家HPV疫苗接种计划.
- 在2023年,9-14岁女孩的加权平均覆盖率为第一个剂量为61.6%,全剂量为47.6%.
- 高中等收入国家显示覆盖率最高 (71.7%的第一剂);大多数评估国家的宫癌发病率正在下降.
结论:
- 全球HPV疫苗接种覆盖率明显落后于90%的目标.
- 迫切需要制定和实施战略,以提高HPV疫苗接种率.
- 宫癌发病率的下降趋势与HPV疫苗接种努力相关.
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