艾滋病毒感染者中抑郁症状严重程度和阿片类药物使用之间的长期双向关联:一项前性队列研究
Alexandria Macmadu1, Yu Li1, Fiona Bhondoekhan1
1Department of Epidemiology, Brown University School of Public Health, 121 South Main Street, Providence, RI 02912, USA.
Addictive behaviors reports
|June 23, 2025
概括
在艾滋病毒感染者 (PLHIV) 中,阿片类药物的使用和抑郁症的严重程度是相关的. 更高的阿片类药物使用增加了抑郁症,更大的抑郁症导致更多的阿片类药物使用,突出显示了一个令人担忧的循环.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 心理健康研究 心理健康研究
背景情况:
- 艾滋病毒感染者 (PLHIV) 中阿片类药物使用和抑郁症状之间的相互作用仍然不充分理解.
- 现有的研究尚未完全阐明这些条件之间的双向关系.
研究的目的:
- 在PLHIV中调查阿片类药物使用频率和抑郁症状严重程度之间的潜在关联.
- 检查抑郁症症状严重程度是否预测该人口中随后的阿片类药物使用频率.
主要方法:
- 从退伍军人衰老队列研究 (VACS) 的数据分析 - 调查样本,PLHIV的前队列.
- 从2002年到2018年评估过去一年的阿片类药物使用频率和抑郁症状严重程度.
- 利用时间滞后的,一般化的估计方程模型来估计双向关联,调整共变量.
主要成果:
- 增加阿片类药物使用频率 (至少每月一次) 与随后更严重的抑郁症状严重程度有关 (aOR=1.44,95% CI:1.22,1.70).
- 在阿片类药物使用和抑郁症严重程度之间观察到剂量反应关系.
- 中度抑郁症状严重程度与随后使用阿片类药物的频率较高有关 (aOR=1.38,95% CI:1.17,1.62).
结论:
- 研究结果表明,在PLHIV中,阿片类药物使用和抑郁症之间存在循环关系.
- 建议加强对物质使用障碍的查,并改善退伍军人PLHIV获得心理健康服务的机会.
- 治疗阿片类药物使用障碍的药物和减少危害的服务应该考虑这个人群.
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