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肝皮微生理系统用于评估局部药物输送引起的肝损伤

Kun Du¹, Bei Wang¹, Ning Yang²

¹Hubei Province Key Laboratory of Skin Infection and Immunity, Wuhan No. 1 Hospital, Wuhan 430022, China.

|June 23, 2025

概括

一个新的肝皮微生理系统 (LS-MPS) 有效地模拟局部药物输送风险. 这种先进的模型有助于评估药物诱导的肝损伤,并增强新药的药物安全性测试.

科学领域:

生物医学工程生物医学工程
毒理学毒理学毒理学
药物输送系统药物输送系统

背景情况:

药物诱导的肝损伤是急性肝衰竭的主要原因,造成严重的健康问题.
局部和透皮药物递送方法越来越受欢迎,需要对其肝毒性风险进行严格的评估.
目前对局部药物诱导肝损伤的现有研究模型有限,阻碍了全面的安全评估.

研究的目的:

开发一种高度仿生的肝皮微生理系统 (LS-MPS),模仿体内肝皮相互作用.
在LS-MPS中建立和描述三维 (3D) 肝脏和皮肤微组织.
评估LS-MPS在评估局部药物输送引起的药物诱导肝损伤方面的潜力.

主要方法:

开发一个动态的LS-MPS,为肝脏和皮肤组织创造一个生理相关的微环境.
在LS-MPS中建立3D肝脏和皮肤微组织,评估细胞活力,结构和功能.
应用LS-MPS来评估与局部药物管理相关的肝毒性.

主要成果:

成功建立具有高细胞活力和仿生特征的3D肝脏和皮肤微组织.
在肝脏微组织中证明了皮肤屏障和透功能以及活跃的代谢功能的维持.
LS-MPS有效地评估了局部输送的药物诱导肝损伤,展示了其在药物安全测试中的实用性.

结论:

开发的LS-MPS为评估复杂药物毒性提供了一个有前途的平台,特别是用于局部和透皮输送系统.
这种先进的模型可以对新药的安全性评估做出重大贡献,降低药物诱导的肝损伤风险.
临床前药物安全测试的LS-MPS提供了一个更准确和生理相关的方法.

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