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相关概念视频

Olfaction01:25

Olfaction

45.2K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
45.2K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

9.6K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
9.6K
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

9.7K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.7K

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相关实验视频

Updated: Sep 18, 2025

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
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Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

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一个完全在的协议,以了解嗅觉受体-嗅觉受体相互作用.

Bhavika Berwal1, Pinaki Saha2, Ritesh Kumar1,3

  • 1CSIR-Central Scientific Instruments Organisation, Chandigarh 160030, India.

ACS omega
|June 23, 2025
PubMed
概括

本研究介绍了一种in silico方法,用于预测嗅觉受体 (OR) 结构及其与气味剂的相互作用. 这种方法提高了对气味机制的理解,并有助于发现新的OR-香味剂对.

科学领域:

  • 计算化学和结构生物学
  • 嗅觉受体研究研究
  • 化学感应机制的化学感应机制

背景情况:

  • 了解嗅觉受体 (OR) - 气味剂相互作用对于嗅觉研究至关重要,但有限的实验数据阻碍了结构性阐明.
  • 需要创新的计算方法来探索嗅觉和OR功能的结构基础.

研究的目的:

  • 开发和验证一个用于预测OR结构和气味相互作用的in silico协议.
  • 为了利用同源的AlphaFold结构来实现混合同源模型策略.
  • 应用管道来识别新的OR-香味剂对并了解结合机制.

主要方法:

  • 开发了一种使用AlphaFold结构和分子动力学模拟用于OR结构预测的混合同质模型策略.
  • 在217个分子的数据库中利用K-最近邻居聚类来选择对接的代表性气味剂.
  • 应用分子对接来研究嗅觉受体 (OR51E2,OR51E1,OR51D1,OR51G2) 和选定的气味剂之间的相互作用.

主要成果:

  • 与独立的AlphaFold模型相比,in silico协议产生了更稳定的OR结构,通过分子动力学验证.
  • 该管道准确地复制了已知的OR51E2-propionate相互作用,并扩展到同类的ORs.
  • 成功验证了超过25个已确定的气味剂-OR关系,并确定了OR51G2.2.的潜在相互作用.

更多相关视频

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Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay
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Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay

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相关实验视频

Last Updated: Sep 18, 2025

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
09:53

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

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High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity
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High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity

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Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay
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Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay

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结论:

  • 开发的计算框架提供了一种有效的方法来预测和表征OR-气味剂对.
  • 这种方法可以加速发现潜在的治疗应用,并促进对嗅觉结合机制的理解.
  • 这项研究为优先考虑嗅觉研究中的实验验证提供了有价值的工具.