Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Association of Serum GFAP with Functional and Neurocognitive Outcome in Sporadic Small Vessel Disease.

Biomedicines·2022
Same author

CSF levels of SNAP-25 are increased early in Creutzfeldt-Jakob and Alzheimer's disease.

Journal of neurology, neurosurgery, and psychiatry·2022
Same author

Glial fibrillary acidic protein in cerebrospinal fluid of patients with spinal muscular atrophy.

Annals of clinical and translational neurology·2022
Same author

Fast versus slow disease progression in amyotrophic lateral sclerosis-clinical and genetic factors at the edges of the survival spectrum.

Neurobiology of aging·2022
Same author

Cognition in the course of ALS-a meta-analysis.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2022
Same author

Increased pyroptosis activation in white matter microglia is associated with neuronal loss in ALS motor cortex.

Acta neuropathologica·2022

相关实验视频

Updated: Sep 18, 2025

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.6K

扩散张力成像对渐进性超核性麻中连续的神经病理模式的扩散张力成像.

Lavinia A Bârlescu1, Günter U Höglinger2,3,4, Heiko Volkmann1

  • 1Department of Neurology, University Hospital Ulm, Ulm, Germany.

Frontiers in aging neuroscience
|June 23, 2025
PubMed
概括

扩散张力成像 (DTI) 在体内绘制了渐进性超核性 (PSP) 的阶段. 这种区域/感兴趣区域 (ROI/TOI) 方法确定了连续的脑部变化,支持DTI作为PSP进展的标志物.

关键词:
扩散张力成像技术 (DTI)神经病理学神经病理学渐进性的超核性麻.一个连续的模式.蛋白质是一种蛋白质.

更多相关视频

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

17.6K
Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

12.4K

相关实验视频

Last Updated: Sep 18, 2025

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.6K
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

17.6K
Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

12.4K

科学领域:

  • 神经成像是一种神经成像.
  • 神经病理学神经病理学
  • 扩散张力成像 (DTI) 是一种扩散张力成像技术.

背景情况:

  • 渐进性超核性麻 (PSP) 的特征是可能遵循一个连续的区域模式的tau包容.
  • 了解PSP体内进展是诊断和治疗的关键.
  • 现有的神经病理阶段概念需要通过体内成像技术进行验证.

研究的目的:

  • 使用DTI开发一种以假设为导向的基于利益的区域/区域 (ROI/TOI) 方法.
  • 在体内分析参与PSP每一个神经病理阶段的大脑区域.
  • 通过使用DTI验证PSP提出的神经病理阶段概念.

主要方法:

  • 分析了两个队列 (队列A:78名PSP患者,63名对照组;队列B:66名PSP患者,44名对照组) 用3.0T和1.5TMRI扫描.
  • 长度随访扫描为A队列中的患者和对照组的一个子集获得.
  • 应用全脑空间统计 (WBSS) 和综合ROI/TOI方法来识别和分析大脑变化.

主要成果:

  • 与对照人群相比,WBSS揭示了PSP患者脑干/中脑,基底和额叶的显著变化.
  • 在纵向数据中,变化更为明显,表明疾病进展.
  • 对ROI/TOI的统计分析表明,受影响结构的顺序模式与定义的神经病理步骤保持一致.

结论:

  • 综合的ROI/TOI DTI方法成功地在体内绘制了PSP疾病阶段的地图,无论是横截面还是纵向.
  • 根据已确定的神经病理阶段,DTI作为一个有价值的技术标志物用于成像PSP进展.
  • 这种基于DTI的方法有可能在未来的MRI和尸检控制研究中对PSP患者进行分层.