甲状腺激素敏感性受损与久坐行为之间的关联:一个横截面研究
Hangzhou Yang1, Jie Kang1, Lingkang Dong2
1Department of General Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in medicine
|June 23, 2025
概括
久坐不动的行为与男性甲状腺激素敏感性受损有关,身体质量指数 (BMI) 起着调解作用. 种族也显著影响了这种关联,突出了复杂的相互作用.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 久坐不动行为是与许多慢性疾病相关的日益严重的公共卫生问题.
- 甲状腺激素的敏感性在代谢调节中起着至关重要的作用.
- 静坐时间和甲状腺激素敏感性之间的相互作用需要进一步研究.
研究的目的:
- 为了研究静坐时间和甲状腺激素敏感性之间的联系.
- 探索这种关系中的潜在调解和调节因素.
主要方法:
- 美国国家健康和营养检查调查 (NHANES) 数据 (2007-2012) 的横截面分析.
- 使用LASSO回归和Boruta算法进行混杂选.
- 采用多变量线性回归和受限立方线 (RCS) 曲线来分析关联和非线性关系.
- 进行了子组和相互作用分析,以探索差异效应.
主要成果:
- 确定了22个重要的混因素,其中身体质量指数 (BMI) 是中心的,并且部分调解了这种关联.
- 在男性中发现静坐时间和甲状腺激素敏感度 (PTFQI) 之间存在显著的线性关联 (P=0.002).
- 在女性中观察到一个无意义的,反向的U形联结.
- 揭示了种族对协会的显著相互作用效应 (P=0.004).
结论:
- 久坐时间与男性甲状腺激素敏感性受损有关,部分由BMI调解.
- 静坐时间和甲状腺激素敏感性之间的关系因性别而异,并且因种族而显著缓解.
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