一个关于生物安全考虑和解决方案的案例研究,用于使用高致病性禽流感病毒在高生物封闭环境中的大型设备进行高致病性禽流感病毒的工作
Nicholas J Chaplinski1, Nancy Mead1, David Haley1
1USDA-ARS (Agricultural Research Service), U.S. National Poultry Research Center, Athens, Georgia, USA.
概括
在牛奶中发现了高度致病性禽流感病毒 (HPAIV),迫切需要对消毒方法进行紧急测试. 连续流动巴氏杀菌 (CFP) 已被证实可以在牛奶中禁用HPAIV,确保牛奶的安全性.
科学领域:
- 食品安全 食品安全
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 高致病性禽流感病毒 (HPAIV),一种潜在的流行病原体 (PPP),已在牛群中检测到.
- 在牛奶中发现高度的传染性HPAIV,这对公众健康构成风险.
- 紧急验证乳制品加工方法来禁用HPAIV是非常重要的.
研究的目的:
- 确认连续流化 (CFP) 有效地使牛奶中的HPAIV无活化.
- 根据"巴氏化牛奶条例",根据HPAIV验证现有的牛奶加工条件.
- 在试点规模的CFP中,制定处理大量HPAIV污染牛奶的生物安全程序.
主要方法:
- 为了进行风险评估,从主题专家和各种来源收集信息.
- 开发了一种新的,大规模的试点系统的程序,每次测试需要5L的高位PPP.
- 设计和实施了具有密封端口,连接和HEPA过通风口的特定应用设备.
主要成果:
- 开发了创新的工程和程序解决方案,以管理大量的传染物质.
- 为专用设备制定了安全程序,包括密封完整性测试.
- 实验设计成功地适应了大规模和高标位的要求.
结论:
- 这项研究成功验证了CFP在乳中禁用HPAIV的有效性.
- 通过工程解决方案和严格的程序,生物安全风险得到了有效的缓解.
- 该研究以时间敏感的方式确保了牛奶加工对HPAIV的安全性.
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