非选择性β-阻断剂与胃患者的死亡率降低有关
Rebecca H Moon1, Joanie Chung2, Paul Chang3
1Department of Gastroenterology, Graduate Medical Education, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California.
Gastro hep advances
|June 23, 2025
概括
非选择性β抑制剂 (NSBBs) 可能会降低胃静脉 (GV) 患者的死亡率. 这项研究发现,与非使用者相比,使用NSBB的GV患者的死亡率较低,这表明潜在的预后益处.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 临床药理学 临床药理学
背景情况:
- 胃静脉 (GV) 是门高血压的一个严重并发症,比食道静脉的死亡率更高.
- 非选择性β抑制剂 (NSBB) 预防胃水出血的有效性尚未得到充分证实.
- 关于NSBBs对GV.患者临床结果的影响的数据有限.
研究的目的:
- 研究非选择性β抑制剂 (NSBBs) 对诊断为胃变节 (GV) 的患者临床结果的影响.
- 为了比较NSBB使用者与GV的非使用者之间的死亡率和其他临床结果.
主要方法:
- 在2015年至2021年期间诊断出GV的1276名患者的回顾性队列研究.
- 结果的比较,包括NSBB用户和非用户之间的出血,肝移植,分流放置和死亡率.
- 用多变量逻辑回归分析来比较结果.
主要成果:
- 与非NSBB组 (50.9%) (OR = 0.62) 相比,NSBB组的死亡率明显较低 (39.2%).
- 对于胃静脉出血,食道静脉出血,肝移植或分流器放置的组之间没有发现显著差异.
- 研究完成后的整体死亡率为40.1%.
结论:
- 非选择性β-阻断剂 (NSBB) 在胃静脉 (GV) 患者的使用与死亡率的降低有关.
- 在现实环境中,NSBBs可能在对GV患者的管理中提供预后益处.
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