与多克索鲁比诱导的男性生殖功能障碍相关的铁和非铁机制
E O Ajani1,2, T M Akhigbe2,3, P A Oyedokun1,2
1Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Toxicology reports
|June 23, 2025
概括
德克索鲁比化学疗法通过ferroptotic和非ferroptotic途径损害男性生殖器官. 研究表明,抗氧化剂可以防止这种损伤,强调需要生育保护策略.
科学领域:
- 生殖毒理学 生殖毒理学
- 在瘤学瘤学.
- 细胞死亡机制 细胞死亡机制
背景情况:
- doxorubicin (DOX) 是一种重要的化疗药物,但对男性生殖器官造成显著的毒性.
- 了解DOX诱导的男性生殖功能障碍的机制对于患者护理至关重要.
研究的目的:
- 审查和综合目前关于DOX诱导的男性生殖毒性的ferroptotic和非ferroptotic机制的证据.
- 探索潜在的保护策略和生育保护的需要.
主要方法:
- 文献综述综合了关于多克索鲁比辛对男性生殖健康影响的现有研究.
- 对参与多克索鲁比毒性的细胞和分子通路的分析.
- 对ferroptosis和抗氧化剂干预措施的新兴证据的审查.
主要成果:
- 通过氧化应激,脂质过氧化,线粒体功能障碍和主要丸细胞的亡,DOX会诱导丸损伤.
- DOX 破坏了下丘脑-垂体-淋巴腺 (HPG) 轴,损害了的产生和精子生成.
- 铁亡被确定为DOX诱导的丸损伤的重要贡献者,具有抗氧化剂 (如黑激素和氧化纳米颗粒) 的潜在保护作用.
结论:
- 由DOX引起的男性生殖功能障碍涉及复杂的ferroptotic和非ferroptotic通路.
- 抗氧化剂疗法显示出减轻DOX诱导的丸损伤的前景.
- 综合性护理方法对于管理癌症治疗副作用和保持生育能力至关重要.
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