CCL2 抑制剂 Bindarit 通过减轻细胞损失相关的血脑屏障破坏和神经炎症来改善术后认知功能
Hui Yuan1,2, Bo Lu1,2, Daofan Sun2
1Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310052, Zhejiang Province, China.
Mediators of inflammation
|June 23, 2025
概括
老年患者的外科神经认知障碍 (PND) 与细胞周围细胞损失有关. 抑制C-C动机化学基因连接体2 (CCL2) 与Bindarit保护的大脑细胞周细胞和血脑屏障,改善手术后的认知功能.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 老年学是指老年学的学科.
背景情况:
- 外科手术周围神经认知障碍 (PND) 是老年手术患者经常出现的并发症,影响恢复.
- 以前的研究将PND与大脑周细胞 (PC) 损失联系起来,但机制尚不清楚.
- 关于C-C动机化学因子连接体2 (CCL2) 的研究涉及其在术后PC损伤,血脑屏障 (BBB) 破坏,神经炎症和认知缺陷中的作用.
研究的目的:
- 研究海马C-C动机化学联体2 (CCL2) 在术后皮质细胞 (PC) 损伤,血脑屏障 (BBB) 破坏,神经炎症和认知功能障碍中的作用.
- 评估Bindarit,一个CCL2抑制剂,在小鼠模型中减轻PND相关并发症的疗效.
主要方法:
- 在16个月大的C57BL/6小鼠身上进行了骨骨折手术,以诱导PND.
- 宾达利特 (每天200毫克/公斤) 在手术前4天内内注射,以降低海马CCL2表达的调节.
- 手术后的评估包括行为测试 (开放场地,新型物体识别),西部涂抹,免疫光和传输电子显微镜 (TEM).
主要成果:
- 宾达里特治疗显著抑制了海马体CCL2表达的手术诱导的增加.
- 宾达里特的使用改善了术后的认知功能,增强了运动活动和短期记忆力.
- 宾达里特通过减轻PC损失,保持紧结蛋白表达 (克劳丁-5,奥克卢丁) 和减少神经炎症 (微细胞和星球细胞激活) 来保持BBB完整性.
结论:
- 用Bindarit准C-C动机化学基因连接体2 (CCL2) 有效地防止细胞周围细胞的损失,保护血脑屏障,缓解神经炎症,从而减少外科外围神经认知障碍 (PND) 的发生率.
- 抑制CCL2代表了一种有前途的治疗策略,用于预防和治疗老年患者的PND.
相关概念视频
00:49The Blood-brain Barrier
49.0K
Overview
49.0K
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
214
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
214
01:20Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
655
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
655
01:27Peripheral Artery Disease III: Interprofessional Care
34
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
34