心胸移植重症监护室的Candida auris爆发:对感染预防实践和跟上不断变化的景观的影响
Shardul N Rathod1, Grace Barajas1, Brooks I Mitchell2,3
1Department of Healthcare Epidemiology and Infection Prevention, Northwestern Memorial Hospital, Chicago, IL, USA.
Infection control and hospital epidemiology
|June 23, 2025
概括
在心胸移植ICU的Candida auris爆发发现了34例病例,干预重点是手部卫生和设备消毒. 这些策略可能有助于解决疫情,表明Candida auris流行病学的转变.
科学领域:
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
- 流行病学 流行病学
背景情况:
- 黄是一种新兴的多抗药性真菌病原体,在全球引起疫情.
- 心胸移植重症监护室 (CTICU) 是由于免疫功能低下的患者而脆弱的环境.
研究的目的:
- 在CTICU中详细说明Candida auris疫情的缓解策略.
- 评估对感染预防 (IP) 实践的影响.
主要方法:
- 从2023年7月到2024年2月在一个大型学术医疗中心进行的回顾性队列研究.
- 多学科团队调查和实施知识产权干预措施.
- 全基因组测序和基因组分析 (WG-SNP) 以确定疫情集群.
主要成果:
- 在CTICU中发现了34例医院发病的Candida auris病例.
- 通过WG-SNP分析,发现了两个不同的爆发群.
- 患者经常有潜在的疾病,如固体器官移植 (32.3%) 或机械循环支持 (35.3%),先前有显著的抗生素暴露 (中位数为22.0天).
- 感染预防 (IP) 干预措施针对手部卫生,设备消毒和环境清洁.
结论:
- 冠状病毒流行病学可能正在转向急性护理机构的流行率增加.
- IP干预措施,特别是加强手部卫生和集中消毒共享设备的干预措施,可能有助于疫情解决.
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