诊断时组织学活性与性结肠炎患者内镜反应之间的临床关联:一项回顾性研究
Jae-Sung Yoo1, Kyeong Ok Kim1, Min Cheol Kim1
1Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.
在性结肠炎 (UC) 诊断时的高组织学活性预测了更糟糕的内镜结果. 高UC活性患者需要更密集的管理,以获得更好的临床结果.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 临床病理学 临床病理学
背景情况:
- 组织学活性与性结肠炎 (UC) 的临床结果有关.
- 了解初始组织学发现和内镜外观之间的关系对于UC管理至关重要.
研究的目的:
- 调查新诊断的UC患者诊断时的组织学活性与内镜发现之间的关联.
- 为了确定最初的组织状况是否预测诊断和随访时内镜疾病的严重程度.
主要方法:
- 对51名新诊断的UC患者的医疗记录进行了回顾性审查 (2015年3月至2022年2月).
- 使用南希组织学指数评估的组织学活性 (低:0-2,高:3-4).
- 用梅奥内镜子评分和性结肠炎内镜重度指数 (UCEIS) 评分内镜活动.
主要成果:
- 在诊断时,初始组织学和内镜活动之间没有显著的相关性 (p=0.200).
- 在第一次随访时,78.4%的患者表现出较低的组织学活性;高活性在治疗后下降.
- 较高的初始组织学活性与第一次随访时的UCEIS分数有显著的相关性 (r=0.37,p<0.001).
结论:
- 在UC诊断时的高组织学活性是随访期间内镜活动的预测指标.
- 诊断时组织学活性较高的患者需要更积极的治疗策略.
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