研究手术前系统性免疫炎症指数在慢性鼻炎中的有用性
Abdullah A Memon1, David M Poetker1, Jazzmyne Adams1
1Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
概括
系统性免疫炎症指数 (SII) 在经历内镜性鼻手术 (ESS) 的慢性鼻炎 (CRS) 患者中较高. 较低的SII与喘和过敏性鼻炎的患病率增加相关,但不是手术程度.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 炎症研究 炎症研究
背景情况:
- 慢性鼻炎 (CRS) 是一种复杂的炎症状况,通常与喘和过敏性鼻炎 (AR) 等并发症有关.
- 由血液细胞计数得出的全身免疫炎症指数 (SII) 已因其在全身炎症的预后价值而得到认可.
研究的目的:
- 调查SII在评估内镜鼻手术 (ESS) 患者的手术范围和CRS相关并发症中的实用性.
主要方法:
- 对147名接受ESS治疗的成年患者进行了13年的回顾性分析.
- 术前使用血小板,中性粒细胞和淋巴细胞计数来计算SII.
- 关于隆德-麦凯分数,手术程度和并发症的数据被采集并使用t测试和千平方测试进行分析.
主要成果:
- 接受ESS的CRS患者与对照人群相比,SII值显著更高 (1479比1007,p=0.013).
- 在SII和并发症之间发现了显著的反向关联;较低的SII (<895.6) 与更高的喘 (p=0.001) 和AR (p=0.0143) 患病率有关.
- 没有观察到SII和隆德-麦凯得分,鼻多重症或经过手术的鼻数量之间存在显著的相关性.
结论:
- 需要ESS的CRS患者显示SII水平升高.
- 与之前的一些研究相反,这项研究表明CRS患者的SII和喘/AR之间存在反向关系,与手术程度无关.
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