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Updated: Sep 18, 2025

A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors
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针对PDZ的基质招募是PP1-Neurabin对特定4E-BP1脱化的主要决定因素

Roman O Fedoryshchak1, Karim El-Bouri2, Dhira Joshi3

  • 1Signalling and Transcription Laboratory, Francis Crick Institute, London, United Kingdom.

eLife
|June 23, 2025
PubMed
概括

蛋白酸酶1 (PP1) 相互作用蛋白 (PIPs) 产生特定的酶复合体. 这项研究揭示了像Phactr和Neurabin这样的不同PIP如何使用不同的机制来精确控制细胞的基质.

关键词:
在 4E-BP1 中.这种药物是Neurabin.在PIPIP中,PIP是PIP.这就是法克特 (Phactr Phactr) 的意思.生物化学 生物化学化学生物学 化学生物学人类 人类 人类 人类 人类 人类 人类在 mTORC1 的情况下,mTORC1 是分子生物物理学分子生物物理学酸酶是一种酸酶.结构生物学结构生物学

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