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Updated: Sep 18, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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METTL3通过通过自介导的IKKε降解抑制干扰素β来调节PRRSV复制

Yunyun Zhai1, Lucai Wang1, Lijie Lv1

  • 1International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.

Journal of virology
|June 23, 2025
PubMed
概括

甲基转移酶类-3 (METTL3) 通过抑制先天免疫力,有助于猪生殖和呼吸系统综合征病毒 (PRRSV) 的复制. METTL3针对IκB激酶-ε (IKKε) 的降解,抑制I型干扰素的产生,并促进PRRSV感染.

关键词:
这就是 IKKεε的意思.在METTL3中,METTL3是METTL3的第一个类型.N6 - 甲基氨酸 (m6A) 的使用.PRRSVV 在这个问题上.在SQSTM1/p62中使用.这是一种I型干扰子.

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