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Updated: Sep 18, 2025

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将生物物理刺激与功能性支架结合起来,以克服当前对外围神经再生的局限性:一篇综述

Larissa Ribeiro Lourenço1, Erik Felix Dos Santos1, Luccas Correa Teruel de Jesus1

  • 1Centro de Ciências Naturais e Humanas (CCNH), Universidade Federal do ABC (UFABC), Brazil. juliana.marchi@ufabc.edu.br.

Biomaterials science
|June 23, 2025
PubMed
概括

外围神经受伤阻碍了恢复,但新的纳米技术和生物物理刺激显示出希望. 将这些策略与神经引导管道相结合,可以改善神经再生和功能结果.

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Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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