患有多动症儿童和青少年的药物不服药
Konstantin Mechler1, Tobias Banaschewski1, Tobias Hellenschmidt2
1Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
儿童和青少年患有注意力缺陷/多动症障碍 (ADHD) 时,不坚持药物治疗是很常见的. 较高的年龄和较低的智力是关键预测因素,突出显示了对一致的遵守监测和障碍管理的需求.
科学领域:
- 儿童精神病学 儿童精神病学
- 神经发育障碍 神经发育障碍
- 药理学坚持研究 药理学坚持研究
背景情况:
- 注意缺陷/多动障碍 (ADHD) 影响全球6-10%的儿科患者.
- 虽然ADHD药物是有效的,但低于最佳的坚持往往会限制治疗的有效性.
- 了解不服从对于优化青少年治疗结果至关重要.
研究的目的:
- 调查儿童和青少年被诊断患有多动症的药物不服药的流行情况.
- 在这个人口群体中确定与药物不服药相关的特定预测因素.
主要方法:
- 德国的TDM-VIGIL研究,一个前性的多中心观测设计.
- 参与者 (N=198,年龄在6-18岁) 患有多动症被评估为使用药物评估问卷 (MAQ) 的不遵守.
- 后勤回归分析确定了不遵守的预测因素.
主要成果:
- 在评估点上,完全服药的坚持率从66.1%到75.4%不等.
- 较高的时间年龄和较低的智商 (IQ) 与增加的不坚持有显著的相关性.
- 性别,疾病严重程度,不良事件,治疗环境和药物类型等因素并不能预测不坚持.
结论:
- 药物不服药在儿童多动症的管理中构成了重大挑战.
- 青春期和较低的认知能力被确定为不坚持的关键风险因素.
- 临床医生必须主动监测患者的坚持并解决个体患者的障碍,以提高治疗的有效性.
更多相关视频
10:02Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
Published on: March 12, 2020
13:09Using Brain Activation nir-HEG/Q-EEG and Execution Measures CPTs in a ADHD Assessment Protocol
Published on: April 1, 2018
相关概念视频
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Drug Therapy
Antianxiety Medications
Drug Abuse and Addiction: Pharmacological Phenomena
Oppositional Defiant Disorder
Diagnostic Criteria and...
Prescription, Nonprescription and Orphan Drugs
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Adrenergic Agonists: Therapeutic Uses
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
