在不同的共聚合物胀骨周围进行骨重塑的数值调查
Amirreza Sadighi1, Mehrangiz Taheri1, Nolan Black1
1Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, Pennsylvania, USA.
概括
控制的共聚合物骨的胀促进了骨密度,而过度的胀导致了再吸收. 优化胀比率对于成功的骨集成和骨质集成至关重要.
科学领域:
- 生物材料科学 生物材料科学
- 生物力学 生物力学
- 计算生物学 计算生物学
背景情况:
- 共聚合物骨在骨科应用中使用.
- 了解它们的卫生机械反应和骨相互作用对于临床成功至关重要.
- 骨重塑受到机械刺激的影响,正如沃尔夫定律所描述的那样.
研究的目的:
- 开发和验证一个计算框架来模拟共聚合物骨的湿力机械反应.
- 为了研究骨的胀对周围骨重塑的影响.
- 为了确定骨密度和成功的骨质整合的最佳膨胀比率.
主要方法:
- 开发了一种高弹性有限元素框架,与基于应变能量密度的骨重塑模型相结合.
- 在牛血清中进行了80/20和90/10比率的自由胀实验,使用共聚合物多孔骨 (聚 [甲基甲酸-共酸]).
- 在不同密度的骨模型中模拟胀,并分析诱导的辐射应力.
主要成果:
- 90/10组合诱导辐射应力导致有利的骨密度 (17.5%-54%).
- 80/20组合导致过度胀,诱导辐射应力超过31MPa,导致过载再吸收,特别是在高密度骨中.
- 在体内羊的研究证实了有关骨重塑反应的计算发现.
结论:
- 共聚合物骨的胀率显著影响骨重塑.
- 控制的胀 (例如,90/10比率) 促进有益的骨密度.
- 过度的胀 (例如,80/20比率) 会导致有害的过载吸收,损害骨质整合.
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