波多黎各青年暴露于暴力和喘内型
Kristina Gaietto1, Molin Yue1, Yueh Ying Han2
1University of Pittsburgh, Division of Pediatric Pulmonary Medicine, Pittsburgh, Pennsylvania, United States.
Annals of the American Thoracic Society
|June 23, 2025
概括
暴露于暴力与波多黎各年轻人的特定喘类型有关,特别是T助手 (T) 2高和T17高的喘. 暴露于暴力和痛苦与T2-low/T17-low喘内型没有关联.
科学领域:
- 环境健康 环境健康
- 免疫学 免疫学 免疫学
- 儿科呼吸系统医学 儿科呼吸系统医学
背景情况:
- 暴露于暴力是儿童喘发展和恶化的已知危险因素.
- 特定的喘内型,以明显的炎症概况为特征,越来越多地得到认可,但它们与暴力暴露的关系仍然未被探索.
研究的目的:
- 调查波多黎各年轻人接触暴力和特定喘内型 (T2-高,T17-高和T2-低/T17-低) 之间的联系.
- 为了确定与暴力相关的痛苦是否与这些喘内型相关.
主要方法:
- 来自波多黎各人的表观遗传变异和儿童喘 (EVA-PR) 研究的数据分析,包括236例喘病例和243例对照病例 (9-20岁).
- 基于鼻上皮表皮的转录基因特征的喘内型划分为T2-高,T17-高,或T2-低/T17-低.
- 评估使用验证的问卷对暴力,枪支暴力和与暴力有关的痛苦的终身和过去一年的暴露.
主要成果:
- 对暴力的终身暴露与T17高喘相关 (OR=1.13).
- 枪支暴力暴露与T2高 (OR=2.49) 和T17高喘 (OR=1.99) 相关.
- 与暴力相关的痛苦与T2高喘相关 (OR=1.69);没有发现与T2低/T17低喘相关.
结论:
- 暴露于暴力和相关的痛苦与波多黎各年轻人的T2高和T17高喘内型有关.
- 这些发现突出了暴力对特定喘炎症通路的影响.
- 该研究强调需要考虑环境暴露,如暴力,以了解喘异质性,特别是在弱势群体.
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