通过皮肤进行部虚神经刺激,在阿片类药物使用障碍患者中,在阿片类药物戒断期间调节前额叶皮质活动
Farhan N Rahman1, Afra Nawar1, Jonathon A Nye2
1School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
概括
通过皮肤进行宫迷走神经刺激 (tcVNS) 可能有助于治疗阿片类药物使用障碍 (OUD). 这种疗法调节了与成相关的区域的大脑活动,当患者看到阿片类药物线索时.
科学领域:
- 神经科学是一个神经科学.
- 成 药物 药物 药物 药物
- 医疗器械 医疗器械
背景情况:
- 阿片类药物使用障碍 (OUD) 带来了重大的健康挑战,治疗选择有限.
- 了解大脑对治疗的反应对于开发新的治疗策略至关重要.
研究的目的:
- 为了研究通过皮肤进行宫迷走神经刺激 (tcVNS) 对大脑活动的影响,以应对Opioid线索在OUD患者中进行戒断.
- 评估tcVNS作为对OUD的潜在干预措施.
主要方法:
- 用放射性标记水的正子发射断层扫描 (PET) 用于脑部成像.
- 在早期康复过程中患有OUD的参与者接受了活跃的tcVNS或假装设备.
- 在暴露于与阿片类药物使用相关的线索期间进行了脑部成像.
主要成果:
- 活跃的tcVNS导致前带状皮质 (ACC),背部ACC和左下额头回形在暗示暴露期间的神经活动增加.
- 在腹状条纹体和轨道前皮层中观察到高活化的趋势.
结论:
- tcVNS证明了调节与阿片类药物成相关的关键大脑区域的能力.
- 这些发现表明tcVNS可以作为一种有价值的辅助疗法来管理OUD.
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