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Updated: Sep 18, 2025

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
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构建一个神经网络模型来定义V(D) J重组的DNA序列特异性

Justin C Harris1, Jennifer N Byrum2, Cooper B McKinney2

  • 1Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences, Oklahoma City, OK 73104, United States.

Nucleic acids research
|June 23, 2025
PubMed
概括

V(D) J重组使用特定的DNA序列称为重组信号序列 (RSSs) 组装抗原受体基因. 我们的研究揭示了RSS七度和非亚美体区域的核酸变化如何影响这一关键的基因组装过程.

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