在使用左心室合指数的慢性冠状动脉综合征中增强风险分层
Ailís Ceara Haney1,2, Janek Salatzki3,4, Yahya Badran3
1Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. ailisceara.haney@med.uni-heidelberg.de.
概括
左心室合指数 (LACI) 预测慢性冠状动脉综合征患者的心力衰竭住院和全因死亡. 这种心血管磁共振成像指标提供了超越传统风险因素的价值.
科学领域:
- 心脏病学 心脏病学
- 心血管成像 - 心血管成像
- 预测 预测 预测 预测 预测
背景情况:
- 慢性冠状动脉综合征 (CCS) 具有显著的心血管风险.
- 在CCS中预测不良结果的预测标记对于患者管理至关重要.
- 心血管磁共振 (CMR) 为风险分层提供了先进的成像能力.
研究的目的:
- 评估左心室合指数 (LACI) 在CCS患者的预后意义.
- 确定通过CMR测量的LACI是否可以预测主要的不良心血管事件 (MACE),心力衰竭住院治疗 (HFH) 和全因死亡.
- 评估超出已确定的临床和成像参数的LACI增量预后值.
主要方法:
- 对613名接受CMR压力测试的CCS患者 (2008-2018) 的回顾性分析.
- LACI计算为左心房与左心室末端透缩体积的比值.
- 主要终点:MACE (心脏死亡,心肌梗塞). 二级终点:高血压高血压,所有原因的死亡. 全球纵向应变也被评估.
主要成果:
- LACI没有显著预测MACE (HR1.01,p=0.07).
- LACI显著预测高血压 (HR1.02,p<0.0001) 和所有原因死亡 (HR1.02,p<0.0001).
- LACI证明了HFH的增量预后价值,独立于临床因素和全球纵向菌株.
结论:
- 在CCS患者中,LACI是所有原因死亡和HFH的重要预测因子.
- 在传统的风险因素和CMR参数之外,LACI提供了HFH的额外预后信息.
- 在患有慢性冠状动脉综合征的患者中,LACI可能会增加风险分层.
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