[从老年人的角度来看,前列腺癌的雌激素剥夺疗法]
A Wiedemann1, K Becher2, A Manseck3
1Urologische Klinik, Lehrstuhl für Geriatrie, Universität Witten/Herdecke, Evangelisches Krankenhaus Witten gGmbH, Pferdebachstr. 27, 58455, Witten, Deutschland. awiedemann@evk-witten.de.
Zeitschrift fur Gerontologie und Geriatrie
|June 23, 2025
概括
前列腺癌的雄激素剥夺疗法 (ADT),用于老年患者的息治疗,抑制. 由于ADT,仔细的风险效益分析至关重要.
科学领域:
- 在瘤学瘤学.
- 老年医学 老年医学
- 内分泌学 在内分泌学.
背景情况:
- 抗雄激素剥夺疗法 (ADT) 是老年患者的症状前列腺癌的息治疗方法.
- 目前的ADT协议涉及双重抑制丸激素合成,使用素激素释放激素 (LH-RH) 类似物或抗剂,与抗雄激素结合.
- 对于高瘤负担或侵袭性疾病,可以考虑使用塔克森,尽管通常保留给抗割的前列腺癌.
研究的目的:
- 为了评估安卓素缺乏治疗 (ADT) 在症状老年前列腺癌患者的息性应用.
- 突出ADT在老年人群中的综合系统性影响和潜在不良事件.
- 要强调在开始对老年人进行ADT之前,需要进行彻底的风险/益处评估.
主要方法:
- 在前列腺癌管理中对雄激素缺乏治疗 (ADT) 原则的审查.
- 对涉及LH-RH类似物/对手和抗雄激素的双重治疗机制的分析.
- 在特定的高风险场景中考虑辅助的税疗法.
主要成果:
- ADT有效地抑制的合成,影响所有依赖的过程.
- ADT与一系列不良影响有关,包括发热,妇产不良,骨质疏松症,,贫血,跌倒,认知衰退,抑郁症,代谢综合征和心血管事件增加.
- 药物相互作用的显著潜力存在于ADT.
结论:
- 老年前列腺癌患者的雄激素剥夺疗法 (ADT) 需要仔细考虑,因为其系统性影响和潜在的不良事件.
- 在对老年患者启动ADT之前,必须进行全面的风险效益分析.
- 在老年人群中,ADT的息性使用需要平衡治疗益处与重大潜在危害.
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