中央早期青春期和精神疾病.
Lars Dinkelbach1,2, Corinna Grasemann3, Cordula Kiewert4
1Department of Pediatrics III, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
JAMA network open
|June 23, 2025
概括
患有中部早熟青春期 (CPP) 的儿童面临更高的心理健康问题风险,包括抑郁症和多动症多动症,在诊断后持续数年. 对精神病症状的早期警对于及时干预至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 儿童和青少年精神病学 儿童和青少年精神病学
- 公共卫生研究 公共卫生研究
背景情况:
- 在生理范围内的早期青春期时间与增加的心理健康风险有关.
- 关于中心早期青春期 (CPP) 和心理健康结果的先前研究尚未得出结论.
研究的目的:
- 为了确定诊断为CPP的患者精神疾病的风险.
- 为了确定在CPP患者中心理病理状况风险增加的关键时期.
主要方法:
- 一项以人口为基础的,回顾性队列研究利用德国医疗保险数据 (大约. 6.5 百万个体).
- 患有CPP的患者与精确匹配的对照组 (性别,出生年份,保险期,肥胖症) 进行了比较.
- 在CPP诊断之前和之后,分析了抑郁症,焦虑症,ODD/CD和ADHD的发病率.
主要成果:
- 1094名患有CPP的患者与5448名对照人群进行了比较.
- 对于任何精神疾病 (aRR 1.48),抑郁症 (aRR 1.73),焦虑症 (aRR 1.45),ODD/CD (aRR 1.76) 和ADHD (aRR 1.53) 的风险显著增加.
- 在诊断前发现了ODD/CD发病率的增加;抑郁症和ADHD风险在诊断后至少8年仍然很高.
结论:
- 中央早期青春期与精神疾病的风险大幅增加有关.
- 有证据表明,CPP对CPP患者的长期心理健康影响.
- 护理人员应对精神症状进行监测,以使早期干预成为可能.
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