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计算机断层扫描的骨质硬化变化预测了骨质细胞转移的前列腺癌的疾病进展和低生存率
Meiting Chen1, Zhenhua Yang2,3,4, Shuai Yang5
1Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
International journal of surgery (London, England)
|June 23, 2025
概括
在前列腺癌 (PC) 中的骨质硬化变化 (OCs) 与骨质细胞转移相关,与更糟糕的生存率有关. 这些OC可能表明PC患者的疾病进展和降低整体存活率.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 放射性无进展生存率 (rPFS) 可能无法完全捕捉前列腺癌 (PC) 的瘤进展.
- 在患有骨质细胞转移的PC患者中,骨质硬化变化 (OCs) 的预后价值尚不清楚.
研究的目的:
- 调查前列腺癌 (PC) 患有骨质细胞转移的前列腺癌患者骨质硬化变化 (OCs) 的预后意义.
- 确定OCs是否可以作为疾病进展和生存结果的生物标志物.
主要方法:
- 分析了一组训练队列 (152名PC患者) 和一组验证队列 (41名PC患者) 患有骨质细胞转移.
- 根据计算机断层扫描 (CT) 发现,患者被分类为有OC和没有OC (NOC) 的组.
- 临床结果,包括rPFS和整体存活期 (OS),在各组之间进行了比较.
主要成果:
- 与没有OC的患者相比,患有OC的患者的放射性进展率显著更高 (72.8%对51.0%).
- 与NOC组相比,OC组的RPFS (11.6个月与52.9个月) 和OS (30.7个月与67.1个月) 显著差.
- 多变量分析证实了OCs是贫困RPFS和OS的独立预后因素,结果得到了外部验证.
结论:
- 骨质硬化变化 (OCs) 与患有骨质细胞转移的PC患者的不良生存结果有关.
- 在这种患者群体中,OCs可以作为潜在的生物标志物来预测疾病进展和减少存活率.
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