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通过使用Kollidone VA64和Soluplus作为聚合物进行固体分散来增强piperine的溶解性:物理化学表征,分子对接和细胞活力测定

Syed Sarim Imam1, Wael A Mahdi1, Sultan Alshehri1

  • 1Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Journal of biomaterials science. Polymer edition
|June 23, 2025
PubMed
概括

配合Kollidone VA64 (KLD) 和Soluplus (SLP) 的皮佩林 (PRN) 的三级固体分散显著提高了PRN的溶解性和溶解率. 与二进制系统和自由PRN相比,这些piperine固体分散也改善了药物释放和细胞活力.

关键词:
这种药物是Kollidone.皮佩林 (Piperine) 是一种天然的糖.这就是Soluplus.分子对接的分子对接.固体分散的散发方式

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