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Updated: Aug 17, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
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基于DNA条形码的多重复合免疫光成像分析FFPE样本从基因重编程的小鼠黑色素瘤

Sachin S Surwase1, Xin Ming M Zhou2, Kathryn M Luly1

  • 1Department of Biomedical Engineering, Johns Hopkins University; Translational Tissue Engineering Center, Johns Hopkins University; Johns Hopkins Translational ImmunoEngineering Center, Johns Hopkins University.

Journal of visualized experiments : JoVE
|June 23, 2025
PubMed
概括

这项研究引入了一种新的DNA条形编码方法,用于在甲固定嵌 (FFPE) 组织中的空间蛋白质组学. 该协议允许开发抗体面板,用于分析FFPE样本中的瘤微环境.

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相关概念视频

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...