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通过竞争性结合,SARS-CoV-2核体蛋白直接阻止了cGAS-DNA的识别

Theresia Gutmann1, David Kuster1, Anthony A Hyman1

  • 1Max Planck Institute of Cell Biology and Genetics, Dresden 01307, Germany.

Proceedings of the National Academy of Sciences of the United States of America
|June 23, 2025
PubMed
概括

SARS-CoV-2 核体蛋白与DNA结合,阻断cGAS-STING通路,并延迟干扰素的产生. 这种病毒免疫逃避机制有助于严重的急性呼吸系统综合征冠状病毒2感染的严重程度.

关键词:
生物分子凝聚剂是生物分子凝聚剂.cGAS 是一个气体.冠状病毒冠状病毒的新冠病毒.天生的免疫系统天生的免疫系统.核体蛋白质是核体蛋白质的一种.

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