蛋白质摄入对IGF1和ROP的影响
Divya Keerthy1,2, Angela Holuba3, David Bateman1
1Morgan Stanley Children's Hospital, Columbia University, New York, NY, USA.
Journal of neonatal-perinatal medicine
|June 23, 2025
概括
在早产婴儿的腹腔营养中较高的蛋白质增加了胰岛素类生长因子1. 这种干预与早产视网膜病变中增加疾病的风险降低有关,这表明对脆弱的新生儿有潜在的益处.
科学领域:
- 新生儿营养新生儿营养
- 儿科眼科 儿科眼科
- 内分泌学 在内分泌学.
背景情况:
- 胰岛素类生长因子1 (IGF-1) 在神经和视网膜发育中起着至关重要的作用.
- 优化IGF-1水平可能有助于预防严重的婴儿疾病,如早产视网膜病变.
- 早产性视网膜病变 (ROP) 是非常低出生体重婴儿的一个重大问题.
研究的目的:
- 研究亲肠道营养中较高蛋白质含量对出生体重非常低的婴儿IGF-1水平的影响.
- 确定增强蛋白质摄入量,IGF-1和早产视网膜病变的发生率之间的关联.
主要方法:
- 对一项涉及早产婴儿 (<1250g) 的前性,双盲,随机对照试验的后期分析.
- 婴儿被随机分配,接受高蛋白质 (4g/kg/d) 或常规蛋白质 (3g/kg/d) 的亲肠营养.
- 每周进行IGF-1测量和定期进行视网膜检查.
主要成果:
- 高蛋白群中的婴儿显示IGF-1水平显著增加21.9% (p=0.03).
- 虽然整体的ROP和严重的ROP与蛋白质摄入量或IGF-1没有显著的关联,但高蛋白质组的加重疾病风险较低 (OR0.17,p=0.02).
- 患有加症的婴儿的IGF-1水平平均低25% (p=0.052).
结论:
- 亲肠道营养中较高的蛋白质摄入与非常低出生体重婴儿的IGF-1水平升高有关.
- 这种营养策略可能会降低患上重症的风险,重症是一种ROP的严重形式.
- 进一步的研究可能会阐明IGF-1在缓解ROP严重性的直接作用.
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