对健康影响的社会决定因素的回顾性研究对临床试验的考虑
Logan Stacey1, Bing Xu1, Crystal Hattum1
1University of South Dakota Sanford School of Medicine.
概括
健康的社会决定因素 (SDOH) 影响癌症临床试验参与. 这项研究发现查患者的年龄,距离和种族存在差异,突出了改善试验准入的领域.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 医疗保健服务研究 医疗服务研究
背景情况:
- 临床试验提供了先进的癌症治疗方法,但患者参与率很低 (2-10%).
- 患者健康的社会决定因素 (SDOH),包括年龄,农村,种族,教育和社会经济地位,影响临床试验招生.
- 了解SDOH对于改善癌症临床试验的准入至关重要.
研究的目的:
- 调查SDOH与临床试验参与之间的关系.
- 确定与大平原社区癌症中心癌症临床试验查相关的特定SDOH因素.
主要方法:
- 从2018-2022年对瘤电子健康记录 (EHR) 的回顾性分析.
- 包括15514名为恶性瘤治疗的患者 (WCP) 和1311名为试验 (SCT) 进行正式查的患者.
- 利用美国人口普查局的城市/农村分类数据和人口统计和试验查文件的EHR数据.
主要成果:
- 与所有接受治疗的患者 (WCP) 相比,接受查的患者 (SCT组) 较年轻 (平均年龄为67.2岁与72.3岁),居住在研究地点较近 (中位数为69.9英里与89.8英里).
- 城市患者在SCT组中占比较高 (32.0%) 比WCP (22.5%).
- 在SCT和WCP群体之间的高加索人群中观察到一个统计学上显著的差异 (94.7%与93.1%,p=0.033).
结论:
- 来自EHR和辅助来源的数据限制可能会影响研究结果的有效性.
- 该研究通过关注SDOH,确定了改善临床试验参与的潜在领域.
- 需要进一步的研究才能充分了解SDOH对临床试验招生的影响.
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