全球脂蛋白 (a) 检测趋势从2015年到2023年
Muhammad Hanif1, Laibah Arshad Khan2, Anandita Kulkarni3
1Department of Medicine, SUNY Upstate Medical University, Syracuse, NY.
American heart journal
|June 23, 2025
概括
全球脂蛋白 (a) [Lp(a) ]测试仍然很低,尽管它作为心血管疾病风险因素的作用. 需要加强教育和指导方针的实施,以提高高风险患者的Lp (a) 测试率.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 脂蛋白 (a) [Lp(a) ]是心血管疾病的一个重要,但往往未测量的风险因素.
- 目前的指导方针主张进行普遍的Lp (a) 测试,特别是在早发心血管疾病或家族病史的人群中.
- 针对Lp的新兴疗法 (a) 强调了识别有风险的个体的临床重要性.
研究的目的:
- 分析过去十年 (2015-2023) 脂蛋白 (a) [Lp(a) ]检测的全球趋势.
- 评估高风险患者子组和关键人口统计数据中的Lp (a) 测试模式.
- 为了确定遵守推的Lp (a) 测试指南的差异.
主要方法:
- 使用TriNetX全球协作网络进行的一项回顾性队列研究.
- 包括在2015年1月至2023年12月期间接受Lp(a) 测试的成年患者 (≥18岁).
- 使用ICD-10-CM代码对并发症的分析和评估整体和高风险人群的年度测试趋势.
主要成果:
- 分析了144个医疗机构的1.41亿患者的数据.
- 总体而言,Lp (a) 测试从2015年的0.009%增长到2023年的0.032%,增长幅度极小.
- 高风险子组 (如冠状动脉疾病,缺血性中风,心力衰竭) 的检测率在2023年仍然低于1%,只有家族病史超过了这一门.
结论:
- 全球脂蛋白 (a) [Lp(a) ]测试率特别低,无论是在一般人群中还是高风险个体中.
- 需要加强教育和系统地实施指南推的Lp (a) 测试.
- 改进的测试策略对于准确的心血管风险分层和及时干预至关重要.
相关概念视频
Blood Studies for Cardiovascular System III: Serum Lipid Profile
298
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
298
Overview of Lipid Metabolism
2.6K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
2.6K
Lipid-derived Compounds in the Human Body
5.4K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
5.4K
Lipid Absorption
859
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
859
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
890
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
890
Lipid Digestion
94.1K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
94.1K


