在孕期或产后接受母体COVID-19疫苗接种后的婴儿抗体
Flor M Munoz1,2,3, Lalitha Parameswaran4, Holly Gundacker5
1Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Pediatrics
|June 23, 2025
概括
孕妇在怀孕期间接种COVID-19疫苗的助推剂显著增加了婴儿的抗体水平,持续六个月. 感染和接种疫苗的混合免疫力进一步增强了新生儿的这些保护性抗体.
科学领域:
- 免疫学 免疫学 免疫学
- 孕产妇和儿童的健康
- 疫苗学 疫苗学 疫苗学
背景情况:
- 孕产妇产生的抗体在保护婴儿方面起着至关重要的作用.
- 了解疫苗接种后的抗体动力学对于婴儿免疫力至关重要.
- 不同的母体疫苗接种计划对婴儿抗体水平的影响需要研究.
研究的目的:
- 描述6个月龄以下婴儿中母性抗体的动力学.
- 为了比较孕期或产后母亲2或3剂COVID-19疫苗接种后的抗体水平.
- 评估母婴COVID-19感染对抗体水平的影响.
主要方法:
- 对接种疫苗的母亲生下的婴儿进行前性,多中心的队列研究.
- 测量结合性,伪病毒和中和性抗体标位在出生时,2个月和6个月.
- 对抗体半衰期的评估以及对母婴COVID-19感染的影响.
主要成果:
- 接受三剂 (增强) 疫苗接种的母亲的婴儿在出生和两个月后的抗体标位显著更高.
- 针对疫苗菌株的抗体标位较高,但不包括Omicron变种,在接受增强疫苗的母亲的婴儿中持续长达六个月.
- 孕产妇的产前疫苗接种和混合免疫 (感染+疫苗接种) 与婴儿抗体标位较高有关.
结论:
- 怀孕期间的母体COVID-19强剂导致婴儿功能性抗体标位与两剂或产后疫苗接种相比显著更高.
- 出生时抗体度高,结合母亲的混合免疫力,导致婴儿抗体水平持续升高六个月.
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