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在怀孕期间处方抗抑郁药的模式:CPRD中的描述性分析

Florence Zoe Martin^1,2,3, Gemma C Sharp^4,5, Kayleigh E Easey^6,5

¹University of Bristol, MRC Integrative Epidemiology Unit, Bristol, United Kingdom of Great Britain and Northern Ireland flo.martin@bristol.ac.uk.

The British journal of general practice : the journal of the Royal College of General Practitioners

|June 23, 2025

概括

在英国,怀孕期间处方抗抑郁药的数量有所增加. 许多妇女在怀孕期间停止服用抗抑郁药,但在分娩后经常重新开始服用,这表明复杂的处方模式.

科学领域:

产科和妇科产科和妇科
精神病学是一个精神病学.
药理学药理学是指药理学的学科.

背景情况:

怀孕中抗抑郁药的使用正在增加,需要更新流行率和处方模式数据.
怀孕期间使用抗抑郁药物的现有估计已经过时了.

研究的目的:

确定英国抗抑郁药处方的流行率和模式,特别是在怀孕期间和周围.
分析1996年至2018年怀孕期间抗抑郁药处方的趋势.

主要方法:

一项使用英国临床实践研究数据链接 (CPRD) GOLD怀孕登记册的药物使用研究.
对1996-2018年期间1,033,783例怀孕的初级保健处方记录的分析.
类别化抗抑郁药的使用为"普遍" (怀孕前和怀孕期间) 或"事件" (怀孕期间新开处方).

主要成果:

在怀孕期间处方抗抑郁药的比例从1996年的3.2%增加到2018年的13.4%.
7.7%的怀孕涉及抗抑郁药的处方,其中19.9%是意外病例.
超过50%的妇女在怀孕期间停止服用抗抑郁药,但超过一半的妇女在分娩后恢复服用.

结论:

在怀孕期间处方抗抑郁药在英国显示出显著的增长趋势.
在怀孕期间停止服用抗抑郁药是常见的,但产后重新开始服用抗抑郁药是常见的.
诸如年龄较小,先前死产和更高的社会经济贫困等因素与怀孕期间停止治疗的增加有关.

关键词:

抗抑郁药是一种抗抑郁药.使用药物使用药物使用.怀孕怀孕怀孕怀孕怀孕

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