相关实验视频

Updated: Sep 18, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

[甲基酸盐在高胆固醇血症患者中的降脂作用]

Jiawen Zhang¹, Yan Zhang², Xia Zhang²

¹NHC Key Laboratory of Public Nutrition and Health, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Wei sheng yan jiu = Journal of hygiene research

|June 23, 2025

概括

在高胆固醇血症患者中,甲基酸盐 (SA) 有效降低高胆固醇和LDL-C. 降脂效应在具有较高基线胆固醇水平的个体中更为明显.

科学领域:

心血管健康心血管健康
营养科学营养科学
生物化学生物化学

背景情况:

高胆固醇血症是心血管疾病的重要危险因素.
饮食干预在管理脂质概况方面发挥着至关重要的作用.
酸是一种可溶性纤维,具有潜在的降脂特性.

研究的目的:

评估甲基酸盐 (SA) 在降低高胆固醇患者血清总胆固醇 (TC) 的疗效.
评估SA对其他脂质参数的影响,包括甘油三 (TG),LDL-C和HDL-C.

主要方法:

一个随机,双盲,受控试验,涉及84名高胆固醇患者 (TC ≥5.2 mmol/L).
参与者被分配到对照组或SA干预组,持续28天.
在干预前和后测量血清脂水平 (TC,TG,LDL-C,HDL-C),并分析变化.

主要成果:

酸没有显著影响体重或BMI.
与对照组相比,SA干预导致血清TC,TG和LDL-C显著降低 (P<0.05).
降脂效应与基线TC水平呈正相关性 (r=0.476,P<0.001),TC≥6.2mmol/L (P<0.01) 患者的降脂效应较大.

结论:

在患有高胆固醇血症的患者中,酸在降低血清TC和LDL-C水平方面表现出显著的有效性.
对于具有较高基线TC水平 (≥6.2 mmol/L) 的个体,SA降低胆固醇的益处尤其显著.
SA代表了一种有前途的食补充剂,用于管理高胆固醇血症.

关键词:

超高胆固醇血症是一种高胆固醇血症.人口差异的人口差异.甲基酸盐的使用方法总胆固醇总的胆固醇.

更多相关视频

Author Spotlight: Advancing Therapeutics with Biocompatible Sodium Alginate Hydrogel Microspheres

Author Spotlight: Advancing Therapeutics with Biocompatible Sodium Alginate Hydrogel Microspheres

Published on: June 7, 2024

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

相关概念视频

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors

α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...

Antianginal Drugs: Calcium Channel Blockers and Ranolazine

Antianginal Drugs: Calcium Channel Blockers and Ranolazine

Angina pectoris, a primary symptom of ischemic heart disease, requires careful pharmacological interventions. In this context, calcium channel blockers (CCBs) and ranolazine have emerged as crucial pharmacotherapeutic agents, providing deep insights into the complexities of angina management.
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...

Lipids: Dietary Sources and Requirements

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...