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Updated: Sep 18, 2025

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
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Published on: November 22, 2019

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天生的免疫和NF-κB通路控制前列腺干细胞的可塑性,重编程和瘤启动

Chen Jiang1, Yura Song1, Sandrine Rorive2

  • 1Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Nature cancer
|June 23, 2025
PubMed
概括

在前列腺基细胞 (BCs) 中删除Pten会触发细胞可塑性和瘤启动. 针对IL-1,JAK-STAT和NF-κB等先天免疫路径,可以抑制这种Pten诱导的重编程,从而提供新的前列腺癌治疗策略.

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