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查时间:肥胖个体HFpEF查的理由和路线图
Anouk Achten1,2, Lukas Peeters3, Geert Verkoulen4
1Department of Cardiology, Maastricht University Medical Centre, Cardiovascular Research Institute Maastricht (CARIM), PO Box 5800, 6202 AZ, Maastricht, The Netherlands. Anouk.achten@mumc.nl.
Heart failure reviews
|June 23, 2025
概括
肥胖症显著增加了心力衰竭与保留射出小部分 (HFpEF) 的风险,导致早期发病. 本综述主张对肥胖个体进行系统的HFpEF查,以便及时诊断和干预.
科学领域:
- 心脏病学 心脏病学
- 代谢疾病 代谢疾病
- 公共卫生 公共卫生
背景情况:
- 肥胖是心力衰竭的主要危险因素,常常导致疾病在十年内更早发病.
- 肥胖个体表现出独特的病理生理学特征,有助于HFpEF的发展.
- 目前的临床指南不建议在肥胖人群中进行系统的HFpEF查,尽管风险增加.
研究的目的:
- 审查在肥胖患者中实施HFpEF查的理由.
- 要突出与肥胖相关的HFpEF的日益增长的患病率,早期发病率和未被认可的临床表现.
- 在这个人口群体中提出针对HFpEF的量身定制的查和诊断途径.
主要方法:
- 讨论将肥胖与HFpEF (炎症,脂肪组织,血液动力学) 联系起来的病理生理机制.
- 对肥胖患者HFpEF目前的诊断局限性的批判性评估 (尿性,心声图).
- 评估现有和新兴的选工具,包括HFpEF-ABA评分.
主要成果:
- 肥胖加快了HFpEF的发病速度,并与特定的病理生理变化有关.
- 现有的诊断方法在肥胖个体中存在挑战.
- 建议采用针对肥胖患者的逐步查方法.
结论:
- 由于疾病负担较高和早期发病,在肥胖个体中对HFpEF进行系统查是有必要的.
- 通过查提前发现可能有助于及时进行干预.
- 需要进一步的前性研究来验证查的有效性,并确定肥胖人口中的HFpEF流行率.
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