益生菌和胃肠道疾病:治疗疗效的总体元分析
Qingfang Zeng1,2, Pingdong Li1, Huaiyang Wu3
1Department of Gastroenterology, The 910 Hospital of the PLA Joint Logistic Support Force, Quanzhou, China.
European journal of medical research
|June 23, 2025
概括
益生菌有望减少常见的胃肠道问题,如腹和恶心. 然而,证据的质量有所不同,需要对这些益生菌益处进行谨慎的解释.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 基于证据的医学是基于证据的医学.
背景情况:
- 益生菌干预越来越多地被探索用于管理胃肠道疾病.
- 症状包括腹,恶心,胀气和胃上部不适.
- 现有研究存在不一致性,需要进行全面评估.
研究的目的:
- 对益生菌对胃肠道症状的疗效进行总体元分析.
- 解决当前科学文献中的不一致性.
- 提供对益生菌对消化健康的影响的可靠评估.
主要方法:
- 在主要数据库 (PubMed,Scopus,Web of Science,Google Scholar) 进行系统的文献搜索,直到2024年6月.
- 包括对益生菌和胃肠道疾病的干预研究的元分析.
- 随机效应建模用于聚合效应大小,具有子组/敏感性分析和AMSTAR 2用于质量评估.
主要成果:
- 益生菌补充剂显著降低了腹,恶心,胃上疼痛,胀气和味觉障碍的风险 (p < 0.001).
- 更短的干预持续时间 (≤ 2-4 周) 和多菌株益生菌显示出增强的效果,特别是对于腹和腹膜疼痛.
- 在包括的研究中发现了中等到高的异质性和低的方法质量.
结论:
- 益生菌在缓解各种胃肠道症状方面表现出潜在的有效性.
- 由于分析研究中的异质性和方法限制,研究结果应谨慎解释.
- 需要进一步的高质量研究来证实这些益生菌的益处.
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