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Updated: Sep 18, 2025

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
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异常的α-synuclein与synaptotagmin 13结合,从而损害了synuclein病变中细胞外囊泡的释放

Yasuo Miki1, Shuji Shimoyama2, Makoto T Tanaka3

  • 1Department of Neuropathology, Biomedical Research Center, Hirosaki University Graduate School of Medicine, Hirosaki, 036-8562, Japan. yasuomiki@hotmail.com.

Translational neurodegeneration
|June 23, 2025
PubMed
概括

异常的α-synuclein (α-Syn) 通过与synucleinopathies中的SYT13相互作用来破坏细胞外囊泡释放. 这一发现为囊泡运输和突触功能障碍提供了新的治疗点.

关键词:
细胞外囊泡中的细胞外囊泡.这里是SNARE综合体.在SYT13中,SYT13是SYT13中的一个.综核蛋白病变 (Synucleinopathy) 是一种同核蛋白病变的疾病.α-Synuclein 是一种蛋白质.

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