便微生物群,胃肠道完整性,炎症和热调节在最近的热病患者和匹配的对照中
Alex A M Gould1, Neil P Walsh2, Michael J Tipton1
1Extreme Environments Laboratory, School of Psychology, Sport, and Health Sciences, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK.
Experimental physiology
|June 24, 2025
概括
胃肠道 (GI) 屏障完整性和微生物组合显示,在运动热病 (EHI) 患者和对照人群之间,差异很小. 这些因素不太可能解释EHI风险或热不耐受.
科学领域:
- 运动生理学 运动生理学
- 胃肠道的健康状况
- 微生物组研究的研究.
背景情况:
- 运动热病 (EHI) 在运动和职业环境中是一个重大问题.
- 胃肠道 (GI) 屏障完整性和肠道微生物群在EHI病因中的作用是假设的,但尚未完全理解.
- 了解这些因素可以为EHI预防和管理策略提供信息.
研究的目的:
- 为了比较便微生物组,肠胃屏障完整性,炎症和热调节在有和没有EHI史的个人之间.
- 在热耐受性评估期间,调查热耐受和热不耐受个体之间的这些参数差异.
- 为了确定GI因素是否有助于EHI风险或热不耐受.
主要方法:
- 在最近的29名EHI患者和29名匹配对照中使用16S rRNA基因测序进行便微生物组分析.
- 测量血液生物标志物用于消化道屏障完整性和运动前后炎症耐热性评估 (HTA).
- 根据HTA结果将参与者分为耐热 (n=46) 和不耐热 (n=12) 组.
主要成果:
- 在EHI患者和对照人群之间,在便微生物组合总体,胃肠道屏障完整性或炎症方面没有显著差异.
- 与热不耐受的人相比,热不耐受的人表现出较低的运动反应和较低的Firmicutes:Bacteroidota比率.
- 热不耐受的人表现出更大的温度调节应变和更高的血[sCD14]水平,表明潜在的肠胃屏障功能障碍.
结论:
- 便微生物组组成和胃肠道屏障完整性在最近的EHI患者和对照人群之间显示出有限的差异.
- 消化道因子的差异不太可能完全解释最近的EHI患者中EHI风险升高或观察到的热不耐受.
- 热调节反应,特别是运动功能和核心体温,以及特定的微生物比率和胃肠道生物标志物,在区分耐热性方面似乎更为关键.
相关概念视频
Increased Body Temperature
2.5K
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
2.5K
Homeostatic Imbalances in Body Temperature
269
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
269
Assessing Body Temperature - Rectal
6.6K
Rectal temperature measurement is considered the most precise method for assessing core body temperature and typically registers higher than oral temperature. For adults, the rectal thermometer should be inserted 1 to 1.5 inches into the rectum to obtain the most accurate reading.
Follow these steps for rectal temperature assessment:
Step 1: Perform hand hygiene and don clean gloves to prevent cross-infection.
Step 2: Position the patient in a side-lying position to better visualize the rectal...
Follow these steps for rectal temperature assessment:
Step 1: Perform hand hygiene and don clean gloves to prevent cross-infection.
Step 2: Position the patient in a side-lying position to better visualize the rectal...
6.6K
Responses to Heat and Cold Stress
13.9K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
13.9K
Body Temperature
3.1K
The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
3.1K
Methods of reducing fever
776
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Pharmacological Methods of Reducing Fever:
776


